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Obesity Rehabilitation
Centre INSULA
Insulaweg 1
83483 Bischofswiesen/Strub

Tel. +49/8652/59-522
Fax +49/8652/59-225
insula-xxl@dw-hohenbrunn.de

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Obesity Rehabilitation Centre INSULA, Bischofswiesen/Berchtesgaden

Scientific contribution
of the Obesity Rehabilitation centre Insula

  1. Hinney A, Bornscheuer A, Depenbusch M, Mierke B, Tölle A, Mayer H, Siegfried W, Hebebrand J. Absence of leptin deficiency mutation in extremely obese German children and adolescents. International Journal of Obesity (letter) 1997; 21: 1190
  2. Hinney A, Barth N, Ziegler A, von Prittwitz S, Hamann A, Hennighausen K, Lentes KU, Heils A, Rosenkranz K, Roth H, Coners H, Mayer H, Herzog W, Siegfried W, Lehmkuhl G, Poustka F, Schmidt MH, Schäfer H, Grzeschik K-H, Pirke KM, Lesch KP, Remschmidt H, Hebebrand J (1997) Serotonin transporter gene-linked polymorphic region: Allele distributions in relationship to body weight and in anorexia nervosa. Life Sciences 61: 295-303
  3. Roth H, Hinney A, Ziegler A, Barth N, Gerber G, Middeke K, Stein K, Hennighausen K, Hager J, Brömel T, Mayer H, Siegfried W, Schäfer H, Remschmidt H, Grzeschik KH, Hebebrand J (1997) Further support for linkage of extreme obesity to the obese gene in a cohort of obese children and adolescents. Experimental and Clinical Endocrinology & Diabetes 105: 341-344
  4. Hamann A, Tafel J, Büsing B, Münzberg H, Hinney A, Mayer H, Siegfried W, Ricquier D, Greten H, Hebebrand J, Matthaei S (1998) Analysis of the uncoupling protein-1 (UCP1) gene in obese and lean subjects: identification of four amino acid variants. International Journal of Obesity 22: 939-41
  5. Hinney A, Becker I, Heibült O, Nottebom K, Schmidt A, Ziegler A, Mayer H, Siegfried W, Blum WF, Remschmidt H, Hebebrand J (1998) Systematic mutation screening of the pro-opiomelanocortin gene: Identification of several genetic variants including three different insertions, one nonsense and two missense point mutations in probands of different weight extremes. Journal of Clinical Endocrinology and Metabolism 83: 3737-3741
  6. Hinney A, Bornscheuer A, Depenbusch M, Mierke B, Tölle A, Middeke K, Ziegler A, Roth H, Gerber G, Zamzow K, Ballauff A, Hamann A, Mayer H, Siegfried W, Lehmkuhl G, Poustka F, Schmidt MH, Hermann H, Herpertz-Dahlmann BM, Fichter M, Remschmidt H and Hebebrand J (1998) No evidence for involvement of the leptin gene in anorexia nervosa, bulimia nervosa, underweight or early onset extreme obesity: Identification of two novel mutations in the coding sequence and a novel polymorphism in the leptin gene linked upstream region. Molecular Psychiatry 3: 539-543
  7. Münzberg H, Tafel J, Büsing B, Hinney A, Mayer H, Siegfried W, Hebebrand J, Matthaei S, Greten H, Hamann A (1998) Screening for variability in the ciliary neurotrophic factor (CNTF) gene: no evidence for association with human obesity. Experimental and Clinical Endocrinology & Diabetes 106: 108-112
  8. Rosenkranz K, Hinney A, von Prittwitz S, Barth N, Ziegler A, Mayer H, Siegfried W, Lehmkuhl G, Poustka F, Schmidt M, Schäfer H, Remschmidt H, Hebebrand J (1998) Screening for mutations in the neuropeptide Y Y5 receptor gene in cohorts belonging to different weight extremes. International Journal of Obesity 22: 157-163
  9. Rosenkranz K, Hinney A, Ziegler A, Hermann H, Fichter M, Mayer H, Siegfried W, Young JK, Remschmidt H, Hebebrand J (1998) Systematic mutation screening of the estrogen receptor beta gene in probands of different weight extremes: identification of several genetic variants. Journal of Clinical Endocrinology and Metabolism 83: 4524-4527
  10. Roth H, Korn T, Rosenkranz K, Hinney A, Ziegler A, Kunz J, Siegfried W, Mayer H, Hebebrand J, Grzeschik KH (1998) Transmission disequilibrium and sequence variants at the leptin receptor gene in extremely obese German children and adolescents. Human Genetics 103: 540-546
  11. Hamann A, Büsing B, Münzberg H, de Weerth A, Hinney A, Mayer H, Siegfried W, Hebebrand J, Greten H (1999) Missense variants in the human cholecystokinin type A receptor gene: No evidence for association with early-onset obesity. Hormone and Metabolic Research 31: 287-288
  12. Hamann A, Münzberg H, Buttron P, Hinney A, Mayer H, Siegfried W, Hebebrand J, Greten H (1999) Missense variants in the human peroxisome proliferator-activated receptor-g2 gene in lean and obese subjects. European Journal of Endocrinology 141: 90-92
  13. Hinney A, Herrmann H, Löhr T, Rosenkranz K, Ziegler A, Lehmkuhl G, Poustka F, Schmidt MH, Mayer H, Siegfried W, Remschmidt H and Hebebrand J (1999) No evidence for an involvement of alleles of polymorphisms in the serotonin 1Dß and 7 receptor genes in obesity, underweight or anorexia nervosa. International Journal of Obesity 23: 760-763
  14. Hinney A, Schmidt A, Nottebom K, Heibült O, Becker I, Ziegler A, Gerber G, Sina M, Görg T, Mayer H, Siegfried W, Fichter M, Remschmidt H, Hebebrand J (1999) Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans. Journal of Clinical Endocrinology and Metabolism 84: 1483-1486
  15. Hinney A, Schneider J, Ziegler A, Lehmkuhl G, Poustka F, Schmidt M-H, Mayer H, Siegfried W, Remschmidt H, Hebebrand J (1999) No evidence for involvement of polymorphisms of the dopamine D4 receptor gene in anorexia nervosa, underweight, and obesity. American Journal of Medical Genetics (Neuropsychiatric Genetics) 88: 594-597
  16. Siegfried W, Siegfried A, Rabenauer M, Hebebrand J (1999) Snoring and sleep apnea in obese adolescents: effect of long-term weight loss-rehabilitation. Sleep and Breathing 3: 83-87
  17. Sina M, Hinney A, Ziegler A, Neupert T, Mayer H, Siegfried W, Blum WF, Remschmidt H, Hebebrand J (1999) Phenotypes in three pedigrees with autosomal dominant obesity due to haplo-insufficiency mutations in the melanocortin-4 receptor gene. American Journal of Human Genetics, 65: 1501-1507
  18. Britz B, Siegfried W, Ziegler A, Lamertz C, Herpertz-Dahlmann BM, Remschmidt H, Wittchen H-U, Hebebrand J (2000) Rates of psychiatric disorders in a clinical study group of adolescents with extreme obesity and in obese adolescents ascertained via a population based study. International Journal of Obesity 24, 1707-1714
  19. Hinney A, Ziegler A, Oeffner F, Wedewardt C, Vogel M, Wulftange H, Geller F, Stubing K, Siegfried W, Goldschmidt HP, Remschmidt H, Hebebrand J (2000) Independent confirmation of a major locus for obesity on chromosome 10. Journal of Clinical Endocrinology and Metabolism 85: 2962-5
  20. Oeffner F, Vornholdt D, Ziegler A, Hinney A, Görg T, Gerber G, Goldschmidt HP, Siegfried W, Wright A, Hebebrand J, Grzeschik KH (2000) Significant Association between a silent polymorphism in the neuromedin B gene and body weight in German children and adolescents. Acta Diabetol 37: 93-101
  21. Hamann A, Brieske C, Tafel J, Buttron P, Schwarzloh B, Münzberg H, Hinney A, Mayer H, Siegfried W, Hebebrand J, Greten H, Algenstaedt P und Ziegler R (2001) Identification of a deletion variant in the gene encoding the human a2A-adrenergic receptor. European Journal of Endocrinology 144: 291-295
  22. Hinney A, Geller F, Neupert T, Sommerlad C, Gerber G, Görg T, Siegfried W, Goldschmidt HP, Remschmidt H, Ziegler A, Hebebrand J (2001) No evidence for involvement of alleles of the 825- C/T polymorphism of the G-protein subunit β3 in body weight regulation. Exp Clin Endocrinol Diabetes 109: 402-405
  23. Oeffner F, Korn T, Roth H, Ziegler A, Hinney A, Hebebrand J, Goldschmidt HP, Siegfried W, Grzeschik KH (2001) Systematic screening for mutations in the human necdin gene (NDN): identification of two naturally occuring polymorphisms and association analysis in body weight regulation. International Journal of Obesity 25: 767-769
  24. Hinney A, Hoch A, Geller F, Schäfer H, Siegfried W, Goldschmidt H-P, Remschmidt H, Hebebrand J (2002) Ghrelin gene: Identification of missense variants and a frameshift mutation in extremely obese children and adolescents and healthy normal weight students. Journal of Clinial Endocrinology&Metabolism 87: 2716-9
  25. Hinney A, Antwerpen B, Geller F, Schäfer H, Siegfried W, Goldschmidt H, Remschmidt H, Ziegler A, Hebebrand J (2002) No evidence for involvement of the calapin-10 gene "high-risk" haplotype combination for non-insulin-dependent diabetes mellitus in early onset obesity. Molecular Genetics and Metabolism 76: 152-156
  26. Saar K, Geller F, Rüschdorf F, Nürnberg P, Friedel S, Schäuble N, Reis A, Siegfried W, Goldschmidt HP, Schäfer H, Ziegler A, Remschmidt H, Hinney A, Hebebrand J. (2003) Genome scan for childhood and adolescent obesity in German families. Pediatrics 111: 321-7
  27. Schäuble N, Geller F, Siegfried W, Goldschmidt HP, Remschmidt H, Hinney A, Hebebrand J. No evidence for involment of the promotor polymorphism –866 G/A of the UCP2 gene in childhood-onset obesity in humans. (2003) Exp Clin Endocrinol Diabetes 111:73-6
  28. Hinney A, Hohmann S, Geller F, Vogel C, Hess C, Wermter AK, Brokamp B, Goldschmidt H, Siegfried W, Remschmidt H, Schafer H, Gudermann T, Hebebrand J. Melanocortin-4 receptor gene: case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene effect for extreme obesity. J Clin Endocrinol Metab. 2003 Sep;88 (9): 4258-67. PMID: 12970296
  29. Reinehr T, Wabitsch M, Andler W, Beyer P, Bottner A, Chen-Stute A, Fromme C, Hampel O, Keller KM, Kilian U, Kolbe H, Lob-Corzilius T, Marg W, Mayer H, Mohnike K, Oepen J, Povel C, Richter B, Riedinger N, Schauerte G, Schmahlfeldt G, Siegfried W, Smuda P, Stachow R, van Egmond-Frohlich A, Weiten J, Wiegand S, Witte S, Zindel V, Holl RW; APV Study Group. Medical care of obese children and adolescents. APV: a standardised multicentre documentation derived to study initial presentation and cardiovascular risk factors in patients transferred to specialised treatment institutions. Eur J Pediatr. 2004 Jun;163(6):308-12. PMID: 15346912
  30. Friedel S, Fontenla Horro F, Wermter AK, Geller F, Dempfle A, Reichwald K, Smidt J, Bronner G, Konrad K, Herpertz-Dahlmann B, Warnke A, Hemminger U, Linder M, Kiefl H, Goldschmidt HP, Siegfried W, Remschmidt H, Hinney A, Hebebrand J. Mutation screen of the brain derived neurotrophic factor gene (BDNF): Identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit/hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet. 2004 Sep 29;132B(1):96-99 [Epub ahead of print] PMID: 15457498

Book chapters with contribution
of the Obesity Rehabilitation Centre Insula:

  1. Siegfried W., Möller Ch.: Das Schlaf-Apnoe-Syndrom, Diagnostik und Therapie in: H. Ehrenberg: Atemtherapie in der Physiotherapie/Krankengymnastik Richard Pflaum Verlag GmbH & Co. KG
  2. Siegfried W., Siegfried A.: Obesidades Extrema e Mórbida in A. Dämaso: Obesidade, MEDSI, Editora Medica e Cientifica Ltda., Rio de Janeiro, 2003
  3. Siegfried W., Siegfried A.: Terapia para Obesidade Extrema in A. Dämaso: Obesidade, MEDSI, Editora Medica e Cientifica Ltda., Rio de Janeiro, 2003
  4. Siegfried W, N. Netzer: Adipositas und Atmung, in: Adipositas bei Kindern und Jugendlichen Springerverlag (2005)
  5. M. Wabitsch, C. Denzer, W. Siegfried, T. Reinehr, W. Kiess.: Pharmakologische Therapie, in: Adipositas bei Kindern und Jugendlichen Springerverlag (2005)
  6. M. Wabitsch, C. Denzer, W. Siegfried, T. Reinehr, A. Wolf.: Chirurgische Maßnahmen, in: Adipositas bei Kindern und Jugendlichen Springerverlag (2005)